Learn all about Megace megestrol acetate , the medication taken to treat and all the side effects associated with the intake of this medicine. In a population pharmacokinetic analysis of plasma dofetilide concentrations, the mean clearance of dofetilide was 15% lower in patients receiving inhibitors of tubular organic cation transport. Females of childbearing potential should be advised to avoid becoming pregnant while receiving megestrol treatment. Swelling of the hands, feet, and ankles due to fluid retention is a common, but not harmful, side effect. Don't breastfeed while taking Megace without talking to your doctor first. A: Weight is best managed through diet and nutrition. Coadministration of entecavir with antiviral drugs known to be eliminated by active tubular secretion did not result in significant drug interactions in studies Indinavir: Major Due to the significant decrease in the exposure of indinavir by megestrol acetate, administration of a higher dose of indinavir should be considered when coadministering with megestrol acetate.
Pregnancy Megestrol is contraindicated during pregnancy. In one study conducted in cancer patients, 20 — 30% have a positive response and 5% of weight gain after 6-8 weeks of treatment. An Introduction to Side Effects of Megestrol Just like any medicine, acetate ® can cause side effects. It may take up to two months of treatment before your healthcare provider can adequately determine whether the medication is working for you. Megestrol acetate is not intended for prophylactic use to avoid weight loss.
Talk to your doctor if this is a concern. Treatment should be supportive and based on symptoms. Measure dosage with calibrated cup, spoon, or oral syringe. Metabolites account for only 5% to 8% of the administered dose and are considered negligible. Megestrol acetate oral suspension contains the following inactive ingredients: alcohol max 0. The medication was withdrawn in some countries in 1970 due to concerns about observed in dogs, but this turned out not to apply to humans.
This interferes with the stimulation of cell growth in estrogen dependent tumor cells. There is no specific antidote for overdose with megestrol acetate oral suspension. Seek medical treatment right away if you experience things like changes in vision or speech, persistent vomiting, or seizures. There is evidence to suggest a local effect as a result of the marked changes brought about by the direct instillation of progestational agents into the endometrial cavity. Missed Dose of Megace If you miss a dose of Megace, take it as soon as you remember. Using this medication might cause your hair to thin but a few weeks after you finished the medications.
Megestrol is inactivated by the liver; however, metabolites account for only 5% to 8% of the administered dose and are considered negligible. There is also thought to be some direct effect on the lining of the uterine wall endometrium. Women of childbearing potential should be advised to avoid becoming pregnant. Warfarin: Moderate At high doses, megestrol may be associated alterations in warfarin pharmacokinetics that may increase warfarin exposure. Always keep all the appointments with your doctor and the lab. Relative affinities % of megestrol acetate Compound Megestrol acetate 65 5 0 30 0 0 0 Notes: Values are percentages %.
The standard dosage for suspension and tablet Megestrol are usually taken several times a day. Failure to recognize inhibition of the hypothalamic-pituitary-adrenal axis may result in death. The possibility of adrenal suppression should be considered in any patient taking or withdrawing from chronic megestrol therapy who presents with symptoms of adrenal insufficiency e. Megestrol Dosing for Breast and Endometrial Cancer The usual recommended dose of megestrol for reducing is 40 mg four times a day 160 mg over the course of the day. Alternate forms of feeding are recommended if megestrol therapy is essential to the mother.
If you get too hot, wear layers of light clothing so you can easily take the clothes off. However, this information is not a substitute for medical advice. Peak concentrations for the tablets occur in 1 to 3 hours. Megace is also contraindicated in patients with thromboembolic disorders. When radiolabeled megestrol acetate was administered to humans in doses of 4 to 90 mg, the urinary excretion within 10 days ranged from 56. Megestrol acetate has not been tested for dialyzability; however, due to its low solubility, it is postulated that dialysis would not be an effective means of treating overdose. Talk to your pharmacist about how to dispose of the medication properly.
It is also used as an appetite stimulant. In 1974, megestrol acetate was approved in the United States for postponement of es- trus and treatment of false pregnancy in dogs. It is specifically a derivative of with a at the C6 position, a between the C6 and C7 positions, and an at the C17α position. To avoid hair thinning, always use a gentle hair product especially baby shampoo. It is imperative that health care providers inform patients of these differences to prevent errors in dosage. Megestrol may put the fetus at risk that can lead to birth defects.